Christina M. Fitzsimmons

PEER REviewed Publications

^ indicates co-first author contribution
^^ indicates co-second author contribution
# indicates co-corresponding author contribution

1. Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma
   Fitzsimmons CM, Mandler MD, Lunger JC, Chan D, Maligireddy SS, Schmiechen AC, Thalalla Gamage S, Link C, Jenkins LM, Crooks DR, Meier JL, Linehan WM, and Batista PJ. NAR Cancer. In Press.

   • 2022 Leading Edge Symposium: https://youtu.be/xL-lE0-Di-c

2. The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors in cancer cells
   Robey RW^, Fitzsimmons CM^, Guiblet WM, Frye WJE, Gonzalez Dalmasy J, Wang L, Huff LM, Ali-Fahmani F, Lipsey CC, Wade HM, Mitchell AV, Maligireddy SS, Jenkins LM, Nikitina T, Zhurkin VB, Piscopio AD, Bates SE, Arda HE, Gottesman MM, Batista PJ. Molecular Cancer Therapeutics. In Press.

3. Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data
   Bryce-Smith S^, Burri D^, Gazzara MR^, Herrmann CJ^, Danecka W^^, Fitzsimmons CM^^, Wan YK^^, Zhuang F^^, Fansler MM, Fernández JM, Ferret M, Gonzalez-Uriarte A, Haynes S, Herdman C, Kanitz A, Katsantoni M, Marini F, McDonnel E, Nicolet B, Poon C, Rot G, Schärfen L, Wu PJ, Yoon Y, Barash Y, Zavolan M. 2023. RNA. 29: 1839-1855.

   • RNA Society 2022: tinyurl.com/22tmekm8

4. Cryptic splice mutation in the fumarate hydratase gene in patients with clinical manifestations of hereditary leiomyomatosis and renal cell cancer (HLRCC) Crooks DR, Cawthon GM, Fitzsimmons CM, Perez, M, Ricketts CJ, Vocke CD, Yang Y, Middleton L, Neilsen D, Schmidt LS, Tandon M, Merino MJ, Ball MW, Meier JL, Batista PJ, Linehan WM. 2023. Human Molecular Genetics, 32(22) 3135–3145.

5. Dual inhibition of histone deacetylases and the mechanistic target of rapamycin promotes apoptosis in cell line models of uveal melanoma.
   Patel RP, Thomas JR, Curt KM, Fitzsimmons CM, Batista PJ, Bates SE, Gottesman MM, Robey RW. 2021. Investigative Ophthalmology and Visual Sciences. Vol.62, 16.

6. Ten simple rules for acing virtual interviews
   Chan D* Fitzsimmons CM^#, Mandler MD, Batista PJ#.
   PLoS Comput Biol 2020. 17(6): e1009057

7. It’s complicated…m6A-dependent regulation of gene expression in cancer.
   Fitzsimmons CM and Batista PJ.
   BBA Gene Regulatory Mechanisms. 2019. 1862, 3, 382-393.

8. Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
   Kundert K,  Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes, BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T. Nature Communications. 2019. (10) Article number: 2127

9. Determinants of tRNA Recognition by the Radical SAM Enzyme RlmN
   Fitzsimmons CM and Fujimori DG.
   PLoS One. 2016. 11(11): e0167298. 

   • JKX Comics "Scientist Spotlight" Feature

accepted

1. The modification landscape of P. aeruginosa tRNAs
   Mandler MD, Maligireddy S, Guiblet WM, Fitzsimmons CM, McDonald K, Warrell DL, Batista PJ.

   • biorxiv: https://www.biorxiv.org/content/10.1101/2024.02.21.581370v1.full

2. The thiol methyltransferase activity of TMT1A (METTL7A) is conserved across species
   Gonzalez-Dalmasy J, Fitzsimmons CM, Frye WJ, Perciaccante AJ, Jewell CP, Jenkins LM, Batista PJ, Robey RW, Gottesman MM. 

   • biorxiv: https://www.biorxiv.org/content/10.1101/2023.11.17.567538v1

Works In Preparation

1. Invited Review: The Role of Methyltransferases in Drug Resistance
   Fitzsimmons CM*, Robey RW*, Batista PJ, Gottesman MM.